• Multiple technologies exist for analyzing the contents of si

  2021-05-18

  

  Multiple technologies exist for analyzing the contents of single cells, including single-cell DNA sequencing, RNA expression analysis, and protein level and activity measurements (Hu et al., 2018; Narrandes & Xu, 2018; Ortega et al., 2017; Wang & Navin, 2015). Single-cell DNA sequencing is generally

• br Structure of USP Schematic representation of

  2021-05-18

  

  Structure of USP7 Schematic representation of the USP7 domain architecture is shown in Fig. 3B. USP7 is a 135 kDa protein that consists of seven domains, including the N-terminal TRAF-like (Tumor necrosis factor Receptor–Associated Factor) domain, followed by the catalytic core domain and the fiv

• br Introduction Schistosomiasis one of the major parasitic d

  2021-05-18

  

  Introduction Schistosomiasis, one of the major parasitic diseases that affect humans in tropical and subtropical countries, is an acute and chronic condition caused by blood flukes (trematode worms) of the genus Schistosoma (World Health Organization, 2014). Schistosomiasis infects over 240 milli

• In some cases more than one

  2021-05-18

  

  In some cases, more than one CYP450 enzyme may be involved in the metabolism of a drug, and an Eadie–Hofstee plot is usually more reliable for assessing the involvement of multiple Bcl Family Set I (Bu, 2006). Therefore, we first plotted the Eadie–Hofstee curves and observed their shape to determin

• Aspartame Several main strategies for targeting E

  2021-05-17

  

  Several main strategies for targeting E3s described in the literature include: in vitro screening using functional assays [86]; computer programs for predicting potential druggable pockets, including those at protein-protein interfaces, and subsequent docking-based in silico ligand screening [87]; f

• br Results br Discussion Taking advantage of the highly

  2021-05-17

  

  Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate Miconazole that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 interactions.

• br As mentioned above defects in the DNA

  2021-05-17

  

  As mentioned above, defects in the DNA ligase IIIα-interacting protein TDP1 have been identified as the cause of the hereditary neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy 1 (El-Khamisy et al., 2005). In addition, defects in two other DNA repair proteins, aprataxin and

• In Senegal malaria remains a

  2021-05-17

  

  In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th

• In this review focusing on biocatalyst formate dehydrogenase

  2021-05-17

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic PFK-015 oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO2 red

• Our data show a site specific interaction

  2021-05-17

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• 4 methylumbelliferone Here we found that these leukotriene a

  2021-05-17

  

  Here we found that these leukotriene antagonists also inhibit the effects of nucleotides acting at P2Y receptors in dU937 cells, which are known to express a number of nucleotide receptors, such as P2Y2 or P2Y4[30]. In an effort to characterize the P2 receptor subtypes subject to negative modulation

• IL is not expressed in tissues constitutively because of its

  2021-05-17

  

  IL-8 is not expressed in tissues constitutively because of its strong chemoattractant, proinflammatory, and angiogenic activities. Rather, it is an inducible factor, produced by a variety of cell types, including leukocytes, fibroblasts, endothelial and epithelial cells, in response to proinflammato

• Meanwhile high levels of extraversion have

  2021-05-17

  

  Meanwhile, high levels of extraversion have been associated with weaker conditioning and faster Forsythoside A learning (Eysenck, 1970). Similar to neuroticism/anxiety, the role of extraversion for fear conditioning and extinction has found only limited empirical support (Rauch et al., 2005) with s

• Two nutrient sensing pathways the cAMP protein kinase A PKA

  2021-05-17

  

  Two nutrient-sensing pathways, the cAMP-protein kinase A (PKA) pathway and the target of rapamycin complex 1 (TORC1) pathway, are implicated in Msn2/4 regulation. Under non-stress conditions, Msn2 localizes in the cytoplasm and is inactivated by both PKA-dependent phosphorylation of the nuclear loca

• We hypothesize that both IGF

  2021-05-17

  

  We hypothesize that both IGF-1-dependent kinase activation and locally synthesized neuroestrogens interactively regulate estrogen receptor activity in neuronal transcription factor in the absence of exogenously applied estradiol. The Neuro-2A cell line was chosen as the model system for these studi

15688 records 651/1046 page Previous Next First page 上5页 651652653654655 下5页 Last page