• In this study cell migration in

  2021-07-02

  

  In this study, cell migration in response to LTD4 exhibited a typical bell-shaped dose-response curve with optimal activity at 10 nM. However, the effect of inhaled CysLTs on airway inflammatory cells in vivo has not been widely reported to date, therefore, the role of CysLTs in the development of a

• Dexamethasone DEX a potent synthetic

  2021-07-02

  

  Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use

• Although the findings detailed above provide ample evidence

  2021-07-02

  

  Although the findings detailed above provide ample evidence that the activity of the CRF1 receptor in the amygdala plays a role in the acute and chronic effects of alcohol exposure, several important areas of investigation remain understudied. The majority of the work on CRF1-alcohol interactions ha

• br Diseases which have been treated with proteins linked to

  2021-07-02

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty Dacarbazine derivatives of human insulin bound to HSA have applications in the treatment of diabetes while paclitax

• 265 3 The effect of the simple dopaminergic tonic phasic mod

  2021-07-02

  

  The effect of the simple dopaminergic tonic/phasic model on cognitive processing has been investigated by a few studies (Nolan et al., 2004; Rosa et al., 2010). Rosa et al. (2010), using a Stroop task that requires different levels of cognitive flexibility and stability, observed an association betw

• br Disclosure and conflicts of interest br

  2021-07-02

  

  Disclosure and conflicts of interest Acknowledgements This research was supported by grant (BT/PR/11293/BRB/10/849/2008) from Department of Biotechnology (DBT), Government of India and a DST YOS Chair Professorship to PB. The mass spectrometry facility is supported by an institutional program

• br Experimental br Declaration of interest br Introduction

  2021-07-02

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR na+/ca2+ exchanger library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was mo

• In summary synthetic routes with moderate to high

  2021-07-02

  

  In summary, synthetic routes with moderate to high yields have been developed to produce difluoro-dioxolo-benzoimidazol-benzamides including reference standards and , and -desmethylated precursors and , and carbon-11-labeled difluoro-dioxolo-benzoimidazol-benzamides target tracers [C] and [C]. The

• Similarly to other investigations the present study found th

  2021-07-02

  

  Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer Spectinomycin hydrochloride hydrate (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic eff

• Considering the divergence of multiple DGAT isoforms we exam

  2021-06-29

  

  Considering the divergence of multiple DGAT isoforms, we examined whether MiDGAT1 and MiDGAT2s utilized different fatty acids as the substrate to synthesize TAGs. GC-MS analysis indicated that C16:0 and C18:0 were the major components of TAGs in yeast cells, and all three MiDGATs displayed the same

• Several reports by us and

  2021-06-29

  

  Several reports by us and others have highlighted that dimerization or oligomerization of DDR1 ECD and DDR2 ECD enhances their binding to triple-helical collagen.18, 19, 22, 28, 29, 30, 31 The ECD of DDRs consists of a discoidin domain and a stalk region. It has been reported that independent Fucoid

• br Acknowledgements br Introduction Anxiety and depression a

  2021-06-29

  

  Acknowledgements Introduction Anxiety and depression are major components of maintaining the cycle of addiction, and are responsible for the negative reinforcement of drug seeking behaviors (Sarnyai et al., 1995, Koob and Le Moal, 2008). Both rats and humans exhibit increased anxiety states du

• The small molecule d mannuronic acid M patented DE has

  2021-06-29

  

  The small molecule β-d-mannuronic Gastrodin (M2000), patented (DE-102016113018.4), has been tested as an anti-inflammatory and a novel immunosuppressive agent in various experimental models such as animal models of immune complex glomerulonephritis, nephrotic syndrome, multiple sclerosis and rheuma

• br Materials and methods br Results

  2021-06-29

  

  Materials and methods Results Discussion Recently it has been found that prostaglandins play an important role in modulating the host immune system [1,3,22,23], and some parasites produce these eicosanoid mediators to survive into their hosts [6,[10], [11], [12],24,25]. The discovery that p

• To respond to the need for QNAT

  2021-06-29

  

  To respond to the need for QNAT, commercial assays have been developed on automated systems. The first reagents for CMV and EBV VLs in whole blood were Abbott RealTime kits on the m2000 SP/RT system (Abbott Molecular Inc, Des plaines, USA) (M2000) [4,5] and Artus QS-RGQ kits on the QIAsymphony RGQ s

15688 records 624/1046 page Previous Next First page 上5页 621622623624625 下5页 Last page