• A single ICV injection of GALP

  2022-06-24

  

  A single ICV injection of GALP stimulated food intake in goldfish at 1h post-administration. This result is similar to that observed in rats, where ICV injection of GALP exerted an acute orexigenic effect [14], [15], [16]. Simultaneously, our findings counter the results found in mice, where central

• br Acknowledgments The authors gratefully

  2022-06-24

  

  Acknowledgments The authors gratefully acknowledge the support provide by National Natural Science Foundation of China (Number 31301415). Introduction β-Galactosidases (EC 3.2.1.23), frequently known as lactases, are widely used in lactose hydrolysis. This disaccharide is present in mammalian

• The highest metabolic stability observed

  2022-06-24

  

  The highest metabolic stability observed for compound 4k (EC50=0.41μM corresponding to 218ng/mL) among the four selected frontrunner candidates was the principal decisive point in nominating this compounds for pharmacokinetic characterization in mice at the dosage of 10mg/kg (administered intravenou

• Recent efforts have also tried to identify cancer subsets th

  2022-06-24

  

  Recent efforts have also tried to identify cancer subsets that are exquisitely responsive to EZH2i apart from those bearing EZH2 gene mutation (Knutson et al., 2012). The dysfunction of SWI-SNF complex, a chromatin-remodeling regulator that partially antagonizes the catalytic function of PRC2 comple

• Gossypol Cyclopamine a steroidal alkaloid type secondary met

  2022-06-23

  

  Cyclopamine, a steroidal alkaloid type secondary metabolite from Veratrum californicum Durand (Melanthiaceae), serves as an anti-Hh constituent blocking the activation of Smo [96,100]. According to previous studies, cyclopamine was shown to inhibit the development of human hepatocellular carcinomas

• Lieber have discussed alcohol outside the context of hepatit

  2022-06-23

  

  Lieber (2000), have discussed alcohol outside the context of hepatitis C infection exerts specific pathologic effects on the liver. Liver biopsies in patients with hepatitis C who drink alcohol are generally consistent with hepatitis C alone, with portal-based pathology, rather than alcoholic injury

• Fluconazole synthesis br Acknowledgements This work was

  2022-06-23

  

  Acknowledgements This work was supported by a grant from the BBSRC (BB/D011809/1) to GJL and The Royal Society to SHS (Uf090321). SIM and AH were the recipients of scholarships from HEC Pakistan. Introduction Iron (Fe) is the fourth most abundant element in the earth’s crust. However, Fe is o

• Phagocytosis was observed at min after

  2022-06-23

  

  Phagocytosis was observed at 60 min after mixing macrophages with microbes (A). The phagocytosis ability (PA) and phagocytosis index (PI) values of the macrophages engulfing the bacteria measured in flow cytometer were shown in histograms (B). Statistical analyses revealed that both the PA and PI va

• Using embelin and its analogs as surrogate GPR agonists we

  2022-06-23

  

  Using embelin and its analogs as surrogate GPR84 agonists we discovered that GPR84 couples to G12 and G13 signaling pathways in addition to Gi, linking receptor function to Rho/Rac signaling and modulation of the cytoskeleton. In primary human macrophages, GPR84 activation leads to Gβγ signaling, Er

• For the study described herein analogues of

  2022-06-23

  

  For the study described herein, analogues of CID1792197 (2) were selected for exploration. There are a variety of reasons for this decision. First, the synthetic approach, described hereafter, is modular in nature to rapidly enable the independent modification of either end of the molecule. Second,

• br Conflict of Interest Both GM and BDH

  2022-06-23

  

  Conflict of Interest Both GM and BDH are shareholders in Caldan Therapeutics, a company exploring potential novel treatments for type 2 diabetes. Acknowledgments Work described herein was supported by Biotechnology and Biological Sciences Research Council [grant BB/K019864/1)] (to GM) and [gr

• We also investigated fat depots in mesenteric

  2022-06-23

  

  We also investigated fat depots in mesenteric and retroperitoneal adipose tissues as well as in the liver and verified a reduction in lipid droplets following exercise or exercise and FS oil treatments in the liver from obese mice. Potential molecular candidates in the modulation of adipose tissue b

• Fig summarizes the underlying mechanism of SB

  2022-06-23

  

  Fig. 7 summarizes the underlying mechanism of SB on inhibiting inflammation and maintaining epithelium barrier integrity in the TNBS-induced colitis model. Our findings not only explained the protective effect of SB on colon health, but also provided evidence that GPR109A likely constitutes a valid

• Foreign polypeptide antigens can be incorporated into VLPs t

  2022-06-23

  

  Foreign polypeptide antigens can be incorporated into VLPs to create “chimeric” structures, either as fusions to either end of the VLP capsid (coat) protein (CP) or as additions to well-presented loops [18]. This kind of direct fusion to the coat is usually good for small peptides, however, larger p

• To overcome these limitations investigators have

  2022-06-23

  

  To overcome these limitations, investigators have developed novel strategies for identifying and purifying gonadotropes from transgenic mouse models. For example, FSH-producing gonadotropes have been tagged in vivo with a transgenic cell surface antigen (H-2Kk) so that they can be purified in vitro

15688 records 411/1046 page Previous Next First page 上5页 411412413414415 下5页 Last page