• Several enzymes in serine and

  2024-07-17

  

  Several enzymes in serine and glycine metabolism have been proposed as biomarkers for cancer stage and prognosis. Phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), and serine hydroxymethyltransferase (SHMT) levels are high in TNBC and low in luminal-A breast cancers (Kim et a

• In summary we identified a novel MLPH ALK fusion in

  2024-07-17

  

  In summary, we identified a novel MLPH-ALK fusion in AST with discordant results of ALK IHC. In order not to overlook ALK-rearranged AST with rare fusion partners on IHC screening, a sensitive IHC method is preferable. Introduction Lung cancer remains the leading cause of cancer related deaths w

• br Materials and methods br Results br Discussion br Competi

  2024-07-17

  

  Materials and methods Results Discussion Competing financial interests Acknowledgements The work was partially supported by grants from the National Natural Science Foundation of China (Grant no. 31530053 and 31401424) and National Science and Technology Support Plan (Grant no. 2013BA

• The macrophage is the major

  2024-07-16

  

  The macrophage is the major cell type responsible for cholesterol uptake and metabolism associated with the initiation and progression of atherosclerosis in focal areas of the arterial subendothelial space. In advanced atherosclerotic lesions of cardiovascular disease, cholesterol-induced macrophage

• Moreover an increase of extracellular calcium stimulates

  2024-07-16

  

  Moreover, an increase of extracellular calcium stimulates BMP-2 expression of pulp gabazine via L-type calcium channel and ERK signaling, which can be attenuated by PD98059 and nifedipine . Dental pulp cells expressed little calcium-sensing receptors . immunohistochemistry staining also shows the

• Ristocetin A sulfate australia Active SI behavior was dose d

  2024-07-16

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p Ristocetin A sulfate australia 1 week later (F3,20 = 8.93, p reflected by % correct) (Figure 4). A preplanned Bonferroni analysis revealed that .25 µg PACAP produced decreases in % correct responses following an e

• Protein blast analysis of the

  2024-07-16

  

  Protein blast analysis of the sequence of globin-B with those of other gpr120 agonist suggests that the globin-B domain in the HemAC-Lm displays only 6% identity and 34% similarity with that of cytoglobin/neuroglobin (Fig. 2). Furthermore, SWISS-MODEL protein modeling also predicts that the His311 i

• Brain biopsy was performed from the white matter

  2024-07-16

  

  Brain biopsy was performed from the white matter lesion around the posterior horn of the right lateral ventricle, and revealed inflammatory demyelination, such as myelin loss with relative preservation of axons, astrocytosis immnolabeled by rp gift card against glial fibrillary acidic protein, infi

• Previous studies have demonstrated the presence

  2024-07-16

  

  Previous studies have demonstrated the presence of soluble NTPDases, 5′-nucleotidase and adenosine deaminase in rat blood serum as well as in human blood (Doleski et al., 2016; Oses et al., 2004; Yegutkin, 1997; Yegutkin et al., 2007). In addition, our earlier reports have shown that these membrane-

• Recently several groups including ours

  2024-07-16

  

  Recently, several groups, including ours, have started to use the C. elegans multi-dendritic PVD neurons as a model system to dissect the molecular mechanisms of dendrite development. During larval development, PVD elaborates complex and stereotyped dendritic arbors by sequentially adding primary (1

• br Trauma and ACEs screening the past

  2024-07-16

  

  Trauma and ACEs screening: the past, present, and future Traditionally, allopathy’s biomedical model has utilized an etic perspective; the outsiders’ view of the problem. Development of diagnostic screening tools requires an etic approach, which relies heavily on a completely objective perspectiv

• Despite functional studies demonstrating the role

  2024-07-16

  

  Despite functional studies demonstrating the role of 5-HT in ureteral contractility, the source of endogenous 5-HT in the ureter is unclear. Since 5-HT-containing enterochromaffin cells, which are present in the gastrointestinal tract, could not be found in the ureter (Nocito et al., 2007, Ripoche,

• Signaling through Axl can lead to activation of the PI

  2024-07-16

  

  Signaling through Axl can lead to activation of the PI3K/Akt and Ras/MAPK pathways which promote cellular phenotypes (e.g., transformation, migration) consistent with pro-survival and pro-metastatic effects., , Inhibition of Axl activity by a variety of approaches (including pharmacologic, dominant

• br Discussion In our current

  2024-07-16

  

  Discussion In our current study, we demonstrated that both the metastatic and recurrent ovarian cancer tissues expressed lower levels of p62 when compared with the patient-matched primary tumor samples. High cysteine protease levels of p62 were associated with long progression-free survival of pa

• br Aurora A Aurora B and Aurora C small molecule

  2024-07-16

  

  Aurora-A, Aurora-B and Aurora-C small molecule inhibitors Nicholas et al. described phenotypic cellular screening of new highly potent and selective class of Aurora kinase inhibitors. Fragment based approach was utilized; core structure of 57 (Fig. 5) was optimized and selective inhibitor 58 (Fi

15683 records 118/1046 page Previous Next First page 上5页 116117118119120 下5页 Last page